• 一个健康的身体,需要时时的保养注意,学习外国人科学的健康生活方式,营养补充疗法。看看美国人、日本人、英国人、法国人是怎么进行健康养生的。
  • 如果您觉得本站对您有帮助,那么赶紧使用Ctrl+D 收藏89养生网吧!
  • 人人知道一个人人都知道的常识性问答网站

海洛因和吗啡成瘾阻滞剂的突破

健康 89xy 2天前 3次浏览

New research has made a tremendous discovery proving that it is possible to block addiction to heroin and morphine, while increasing pain relief at the same time.

According to the scientists, from the University of Adelaide and the University of Colorado, they have identified the key mechanism in the body’s immune system that intensifies addiction to these potentially harmful drugs.

After much research, the experts learned that the drug (+)-naloxone can selectively block this immune-addiction response.

This finding, published in the Journal of Neuroscience
, is a huge breakthrough which could potentially even lead to new treatment drugs that could reduce the severe pain of users while kicking their habit.

Dr. Mark Hutchinson, lead author of the study and ARC Researcher at the University of Adelaide’s School of Medical Sciences, explained:

“我们的研究已经决定性地表明,我们可以通过大脑的免疫系统来阻止成瘾,而不用针对大脑的线路。中枢神经系统和免疫系统在成瘾中起着重要作用,但我们的研究表明,我们只需要阻断大脑中的免疫反应,就可以防止对阿片类药物的渴望。”

Opioid drugs interfere with normal brain activity which causes a reduction in pain. The drug binds to certain receptors in the brain called opiate receptors, causing the drug to act like naturally occurring opioids in the brain, such as endorphins. This not only reduces the person’s pain but also gives them a euphoric feeling.

Opium and heroin are known as street opioid drugs, because they are not prescription drugs. Examples of prescription opioid drugs, which are sometimes used instead to get high, include:

  • 吗啡
  • 可待因
  • 美沙酮
  • 氢可酮
  • 芬太尼
  • 氢吗啡酮
  • 羟考酮
  • 止痛剂
  • 曲马多
  • 舒芬太尼
  • In order to find a way to shut down the addiction to those drugs, the researchers focused their efforts on the immune receptor known at Toll-Like receptor 4 (TLR4). “Opioid drugs such as morphine and heroin bind to TLR4 in a similar way to the normal immune response to bacteria. The problem is that TLR4 then acts as an amplifier for addiction,” Dr. Hutchinson said.

    “The drug (+)-naloxone automatically shuts down the addiction. It shuts down the need to take opioids, it cuts out behaviors associated with addiction, and the neurochemistry in the brain changes- dopamine, which is the chemical important for providing that sense of ‘reward’ from the drug, is no longer produced,” he continued.

    Senior author Professor Linda Watkins, from the Center for Neuroscience at the University of Colorado Boulder, revealed how their finding fundamentally changes previous knowledge on these drugs. “We’ve suspected for some years that TLR4 may be the key to blocking opioid addiction, but now we have the proof.”

    Watkins concluded:

    “我们用来戒毒的药物(+)-纳洛酮是一种非阿片类镜像药物,由肯纳·赖斯博士在20世纪70年代发明。我们认为,这将被证明是一种非常有用的与吗啡混合的药物,这样那些需要缓解严重疼痛的患者就不会上瘾,但仍然可以获得疼痛缓解。这有可能导致病人和姑息治疗的重大进步。”

    Authors hope clinical trials will be possible within the next 18 months.

    Written by Sarah Glynn


    89养生网, 版权所有丨如未注明 , 均为原创丨本网站采用BY-NC-SA协议进行授权
    转载请注明原文链接:海洛因和吗啡成瘾阻滞剂的突破
    喜欢 (0)